Home > Uncategorized > Respiratory Physiology Lecture 4 Notes: Acid Base Chemistry

Respiratory Physiology Lecture 4 Notes: Acid Base Chemistry

Overview

Today we’ll spend 43 minutes on the acid base chemistry of the lungs.

https://www.youtube.com/watch?v=eeQlkZkCcNY

Details

The lungs and the kidneys are the organs that control acid base status. 

Bronsted acids donate H+ in slution.  Baces accept H+.  A buffer is a substance that can reversib bind hydrogen ions. 

Blood Buffers

H+ + Pr = HPr

H+ + HPO4- = H2PO4

H+ + HCO3- = H2CO3

K = H+ HCO3-/H2CO3

pH = pK + log HCO3-/0.03 pCO3

The Henderson Hasselbach Equation

pH= 6.1 + log (24/]0.03 x 40])

pH = 7.4

The Davenport diagram shows plasma bicarbonate versus pH.  Bicarbonate is HCO3-.  The lower the bicarb concentration, the lower the pH

Respiratory acidosis- raise pCO2.  pH increases. 

Respiratory alkalosis – lower pCO2, lower pH. 

Metabolic acidosis – change in bicarbonate, lower.  pH decreases. 

Metabolic alkalosis –  an increase in bicarbonate levels. 

The O2 Transport System

Oxygen in from ventilation, diffusion, perusion, diffuison. 

Oxygen out by tissue, heart and circlatiion, lungs. 

Volume of gas = area/thickness x diffusivity x pressure difference

Diffusivity = solubility/sqrt MW

Mitochondria get upset when pO2 falls too much. 

hypoxic hypoxia at high heights.

anemic hypoxia comes from low O2 carry capatcity.

circulatory hypoxia is a general decreased in cicrulation.

histotoxic hypoxia is when a poison in the tissue prevent oxygen utilization.

Review

Visible Light – 400 to 700 nm

Aromatic: planar, cyclic, Huckels Rule – 4n+2 electrons

Fibrous – sclera, cornea

Sensory – retina

Vascular – choroid, iris, pupil, ciliary body

Kingdoms – monera, protista, fungi, plant, animal

HSbF6 pKa = 25

Electrophiles are positive, nucleophiles are negative

EDTA is a tetraprotic acid.

Advertisements
Categories: Uncategorized
  1. No comments yet.
  1. No trackbacks yet.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: