Home > Uncategorized > Respiratory Physiology Lecture 6 Notes: Pulmonary Blood Flow

Respiratory Physiology Lecture 6 Notes: Pulmonary Blood Flow

Overview

Today we’ll study pulmonary blood flow for 52 minutes. 

https://www.youtube.com/watch?v=F6bgX3-bEts&feature=bf_next&list=SPE69608EC343F5691

Details

Everything we stury today details transfer of oxygen from the lungs towards the body.

Pulmonary is from the RV to the LA.  Systemic is from the LV to the RA. 

Vascular resistance = pressure drop/flow

The VR on the systemic side is 10x that of the pulmonary side.  Inside the pulmonary capillaries, the pressure is quite small.  Pulmonary capillaries have very thin walls, reflecting their pressure. 

alveolar vessels and extraalveolar vessels are not exposed to alveolar pressure.  They tend to become smaller. 

Electrical Resistence = R = V/I

Vascular Resistance = input pressure – output pressure/flow

Vascular resistance

Recruitment is when all capillaries expand.  distension is increasing the cross section. 

Lung volume versus resistance curves open upwards and have a minimum. 

Fick Principle

Volume per Unit TIme in Oxygen = CaO2 – CvO2

x1qq = Vo2/(CaO2-CvO2_

radioactive xenon into the veins.  The distance up the lung varies.  The bottom is high, the higher up the lung, the less air used.  The upper lung is a no flow zone with little perfusion, little air flow. 

Zone 1, zone 2, zone 3 of the lungs.

Non Gravitational Causes For Uneven Flow

Random variations in the resistance of the blood vessels. 

Some evidence that proximal regions of the acinus get more blood than distal regions.

In some animals some regions of the lung have an intrinsically higher vascular resistance. 

Breathing in a low oxygen environment causes hypoxia in the alveoli. Hypoxic pulmonary vasoconstriction.

Evolutionary pressures For HPV   

Pulmonary blood flow is only about 15% of the cardiac output.

Most of the output of the RV bypasses the through the ducturs ateriosus

THe pulmonary vascular resistence is high because of vasoconstriction in the muscular pulmonary

Immediately after birth, pulmonary blood flow must increase dramatically

Fall in PVR is due to the release of hypoxic vasoconstriction

The Ductus ateriosus closes in time

Substances Metabolized by Lung Tissue:

Angiotensin 1 made into a vasoconstrictor AT2 via ACE.

Steratonin, prostaglandings E1 E2 F2alpha, norephinpherine, arachidonic acid metabolites – leukotrienes, immunogloulins in bronchial mucus. 

Review

CARVER is an acronym that stands for Criticality, Accessibility, Recuperability, Vulnerability, Effect and Recognizability.

Wind Speed Beaufort Category How to Judge the Wind
1-3 mph Light Air Smoke drifts. Wind cannot be felt.
4-7 mph Light Breeze Wind felt on face. Leaves rustle. Weather vanes move.
8-12 mph Gentle Breeze Leaves and twigs in motion. Light flags are extended.
13-18 mph Moderate Breeze Wind raises dust and loose papers. Small branches move. Flags flap.
19-24 mph Fresh Breeze Small trees in leaf sway slightly. Wavelets form on ponds and lakes.
25-31 mph Strong Breeze Large branches move. Telephone lines sing.

Visible Light – 400 to 700 nm

adam boy charles david edward frank george henry ida john kevin lincoln mary nora ocean paul queen robert sam tom union victor william xray young zebra
bull spread buy near, sell far
bear spread sell near, buy farcash – futures = basis

spreads are differences between futures contract months
cashpostive carry
cash>futures negative carry (inverted)
Basis: time space quality

Aromatic: planar, cyclic, Huckels Rule – 4n+2 electrons

Fibrous – sclera, cornea

Sensory – retina

Vascular – choroid, iris, pupil, ciliary body

Kingdoms – monera, protista, fungi, plant, animal

HSbF6 pKa = 25

Electrophiles are positive, nucleophiles are negative

EDTA is a tetraprotic acid.

Tissue: nervous muscular epithelial connective

Epithelial: simple stratified pseudostratifed/ cuboidal columnar squamous

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