Home > Uncategorized > University of Hawaii: Antimicrobial Agents 5.2

University of Hawaii: Antimicrobial Agents 5.2

Overview

Today is all about STDs.  The lecture will last 50 minutes.

https://www.youtube.com/watch?v=bSoYuurNx2w

Details

Trichomoniasis is a common STD.  8 milion new cases each year in men and women.  It’s got flagella and it swims around. 

Protozoa

Amoeba looks like a bunch of grapes

Paramecium have many cilia

Euglena have one flagella

Disulfram reactions lead to vomiting. 

Gonorrhea is an STD caused by a gram negative, intracellular, diplococcus.  Infection of the joints in the young is assumed to be gonorrhea.

Conjunctivitis is an eye infection.  Antibiotic ointment placed in the baby’s eyes at birth. 

Chlamydia is caused by a bacterium, can damage female reproductive organs. 

Pelvic Inflammatory Disease (PID) is again for women.

 Syphillis is the great imitator, caused by a bacterium.  Marked by a sore.  Incubation time average of 21 days.  If untreated, progresses to skin rash and mucous membrane lesions.  Can reach the brain, the internal organs. 

Hepatitis C is a liver disease. 

Tuberculosis is spread from person to person in the air.  Affects the lungs.  Mycobacteria have a relatively impermeable cell wall.

Antifungal Agents

Systemic agents, Oral use, Topical creams

Malaria is caused by mosquito born Plasmodium.  500 million cases worldwide.  Below 20 degrees C, Plasmodium cannot complete its growth cycle.

Canada Dry used to have quinine in them. 

Review

R-(O=S=O)-NH2 is a sulfonamide

The beta lactam ring is a (C=O)NHCH2CH2

Chloramine – NHCl2, NH2Cl, NCl3

Nitroso R-N=O

Nitrous Acid R-O-N=O 3.4

Cyanate H-N=C=O

shape shine shadow silhoutee

mEq = AW / (V x 1000)

horizontal/vertical/diagonal spread

30 households per man per hour, 100 men, 1000 houses, 3 hours

pH = pK + log base/acid

  • Stay relaxed
  • Weapon moves first
  • Accelerate the weapon
  • Move towards the target
  • Penetrate

Acetyl COCH3

Thionyl chloride SOCl2

Barchan Dune 35 degrees down, 15 up

R-N=N-R Azo

Ambush – linear, L, V

C=S Thioketone

H2N(C=O)NH2 Urea

cash-futures = basis

+ basis negative carry

– basis positive carry

4 carbons overwhelm hydrogen bonding

Atmosphere: troposphere, stratosphere, mesosphere, thermosphere, ionosphere, exosphere

CTLSC 7 12 554

Sextuple Bond: Mo2, W2

Intermolecular Bonding: electrostatic, h bonding, dipole dipole, van der Waals

Hydrogen Bonding: FON Cl

Mandatory Refusal – when communications are lost, no one is trusted. A breach is assumed.

Gain Band Width Product = Gain x Bandwidth

CARVER is an acronym that stands for Criticality, Accessibility, Recuperability, Vulnerability, Effect and Recognizability.

Wind Speed Beaufort Category How to Judge the Wind
1-3 mph Light Air Smoke drifts. Wind cannot be felt.
4-7 mph Light Breeze Wind felt on face. Leaves rustle. Weather vanes move.
8-12 mph Gentle Breeze Leaves and twigs in motion. Light flags are extended.
13-18 mph Moderate Breeze Wind raises dust and loose papers. Small branches move. Flags flap.
19-24 mph Fresh Breeze Small trees in leaf sway slightly. Wavelets form on ponds and lakes.
25-31 mph Strong Breeze Large branches move. Telephone lines sing.

Visible Light – 400 to 700 nm

adam boy charles david edward frank george henry ida john kevin lincoln mary nora ocean paul queen robert sam tom union victor william xray young zebra
bull spread buy near, sell far
bear spread sell near, buy farcash – futures = basis

spreads are differences between futures contract months
cashpostive carry
cash>futures negative carry (inverted)
Basis: time space quality

Aromatic: planar, cyclic, Huckels Rule – 4n+2 electrons

Fibrous – sclera, cornea

Sensory – retina

Vascular – choroid, iris, pupil, ciliary body

Kingdoms – monera, protista, fungi, plant, animal

HSbF6 pKa = 25

Electrophiles are positive, nucleophiles are negative

EDTA is a tetraprotic acid.

C-C=O-C Ketone

Ketones containing alkene and alkyne units are often called unsaturated ketones.

Ph2CO Benzophenone

Sunflower 8 benzenes fused together

(H3C)(CO)(CO)(CH3) Diacetyl

Butanone MEK

Acetoin (H3C)(CO)(COH)CH3

Tissue: nervous muscular epithelial connective

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