Home > Uncategorized > University of Hawaii: Histamine 5HT Ergots

University of Hawaii: Histamine 5HT Ergots

Overview

Today’s lecture is 48 minutes long.  We’ll be studying 3 chemical families. 

https://www.youtube.com/watch?v=LAlwVSK6Lqc

Details

Histamine and Serotonin (5HT) are biologically active amines that are also NTs, also used in non neural tissues.

autocoids = self remedy 

Histamine mediates allergic and inflammatory reactions.  Gastric acid secretion.  Chemotaxis of WBCs.  Formed from histadine.  Mast cell and basophils release histamine when antigens contact IgE antibodies; this requires Ca2+ and energy.  Causes vasodialation and capillary leakage, allowing immune components into the area.

There are 4 histamine receptors.  H1 is found on smooth muscule and endothelium.  H2 on gastric mucosa.  H1 blockers are anti-histamines.  H3 are found in the gut nerves.  H4 on WBCs. 

Stimulates sensory nerve endings, pain and itching.  Mosquito bites.  Bronchoconstriction; people with asthma are histamine sensitive. 

Histamine and epinephrine are physiologic antagonists. 

Serotonin or 5 hydroxytryptamine.  A vasoconstrictive substance released from blood clots.  5HT is a NT, a hormone in the gut.  Is metabolized into 5 hydroxyindolacetic acid by MAO. 

SSRIs for depression, anxiety, and OCD. 

Ergot Alkaloids

…made by a fungus that infects grains.  This fungus makes a wide range of biologically active products.  It can be found on moldy grain. 

LSD is a synthetic ergot alkaloid iwth 5HT2 properties. 

Review

G = H-TS = -RTlnK = -nFE

A lactone is a cyclic ester

R-(O=S=O)-NH2 is a sulfonamide

The beta lactam ring is a (C=O)NHCH2CH2

Chloramine – NHCl2, NH2Cl, NCl3

Nitroso R-N=O

Nitrous Acid R-O-N=O 3.4

Cyanate H-N=C=O

shape shine shadow silhoutee

mEq = AW / (V x 1000)

horizontal/vertical/diagonal spread

30 households per man per hour, 100 men, 1000 houses, 3 hours

pH = pK + log base/acid

  • Stay relaxed
  • Weapon moves first
  • Accelerate the weapon
  • Move towards the target
  • Penetrate

Acetyl COCH3

Thionyl chloride SOCl2

Barchan Dune 35 degrees down, 15 up

R-N=N-R Azo

Ambush – linear, L, V

C=S Thioketone

H2N(C=O)NH2 Urea

cash-futures = basis

+ basis negative carry

– basis positive carry

4 carbons overwhelm hydrogen bonding

Atmosphere: troposphere, stratosphere, mesosphere, thermosphere, ionosphere, exosphere

CTLSC 7 12 554

Sextuple Bond: Mo2, W2

Intermolecular Bonding: electrostatic, h bonding, dipole dipole, van der Waals

Hydrogen Bonding: FON Cl

Mandatory Refusal – when communications are lost, no one is trusted. A breach is assumed.

Gain Band Width Product = Gain x Bandwidth

CARVER is an acronym that stands for Criticality, Accessibility, Recuperability, Vulnerability, Effect and Recognizability.

Wind Speed Beaufort Category How to Judge the Wind
1-3 mph Light Air Smoke drifts. Wind cannot be felt.
4-7 mph Light Breeze Wind felt on face. Leaves rustle. Weather vanes move.
8-12 mph Gentle Breeze Leaves and twigs in motion. Light flags are extended.
13-18 mph Moderate Breeze Wind raises dust and loose papers. Small branches move. Flags flap.
19-24 mph Fresh Breeze Small trees in leaf sway slightly. Wavelets form on ponds and lakes.
25-31 mph Strong Breeze Large branches move. Telephone lines sing.

Visible Light – 400 to 700 nm

adam boy charles david edward frank george henry ida john kevin lincoln mary nora ocean paul queen robert sam tom union victor william xray young zebra
bull spread buy near, sell far
bear spread sell near, buy farcash – futures = basis

spreads are differences between futures contract months
cashpostive carry
cash>futures negative carry (inverted)
Basis: time space quality

Aromatic: planar, cyclic, Huckels Rule – 4n+2 electrons

Fibrous – sclera, cornea

Sensory – retina

Vascular – choroid, iris, pupil, ciliary body

Kingdoms – monera, protista, fungi, plant, animal

HSbF6 pKa = 25

Electrophiles are positive, nucleophiles are negative

EDTA is a tetraprotic acid.

C-C=O-C Ketone

Ketones containing alkene and alkyne units are often called unsaturated ketones.

Ph2CO Benzophenone

Sunflower 8 benzenes fused together

(H3C)(CO)(CO)(CH3) Diacetyl

Butanone MEK

Acetoin (H3C)(CO)(COH)CH3

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