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University of Hawaii: Autonomic Pharmacology


This is supposedly the most difficult area of pharamcoology and it’ll cost us 59 minutes. 



There are 4 combinations = +/- the SNS, +/- the PNS.  Agonist/antagonist SNS, agonist/antagonist PNS.

SNS is fight or flight.  PNS is rest or digest system. 

Autonomic means automatic.  ANS contrfol many organs, so drugs affecting the ANS hit man y organs. 

PNS is outside fo the skull and spinal cord.  Here neurons end on organs.  The CNS is the brain and spinal cord.  Neurons end on on other neurons. 

The ANS has two branches: SNS and PNS. 

Adrenaline raise HR, systemic vessels constrict,

Blood vessels have adrenergic alpha one receptors.  Very sensitive to epinephrine and norepinephrine.  Beta receptors are on the heart.  The lungs have beta two receptors. 

Today the environment is dominated by stress, not relaxation. 

Adrenergic agonists are sympathomimetics. 

increase HR, dilate lungs, dilate pupils, constrict BVs.

Beta blockers are adrenergic antagonists and treat high BP. 

The PNS uses ACh and Muscurinic receptors. 

stygmines are ACh-estetase inhibitors

Asthma uses beta agonists or choline muscarinics. 

Positive chronotropes are drugs that cause tachycardia.  Positive intropes increase the force of contraction.  Slow HR are called negative chronotropes.  Bradycardia is a slow heart rate.



ONC octa nitro cubane

Schiff Base C=N-R

acetic acid 4.76
methanol 15.2

G = H-TS = -RTlnK = -nFE

A lactone is a cyclic ester

R-(O=S=O)-NH2 is a sulfonamide

The beta lactam ring is a (C=O)NHCH2CH2

Chloramine – NHCl2, NH2Cl, NCl3

Nitroso R-N=O

Nitrous Acid R-O-N=O 3.4

Cyanate H-N=C=O

shape shine shadow silhoutee

mEq = AW / (V x 1000)

horizontal/vertical/diagonal spread

30 households per man per hour, 100 men, 1000 houses, 3 hours

pH = pK + log base/acid

  • Stay relaxed
  • Weapon moves first
  • Accelerate the weapon
  • Move towards the target
  • Penetrate

Acetyl COCH3

Thionyl chloride SOCl2

Barchan Dune 35 degrees down, 15 up

R-N=N-R Azo

Ambush – linear, L, V

C=S Thioketone

H2N(C=O)NH2 Urea

cash-futures = basis

+ basis negative carry

– basis positive carry

4 carbons overwhelm hydrogen bonding

Atmosphere: troposphere, stratosphere, mesosphere, thermosphere, ionosphere, exosphere

CTLSC 7 12 554

Sextuple Bond: Mo2, W2

Intermolecular Bonding: electrostatic, h bonding, dipole dipole, van der Waals

Hydrogen Bonding: FON Cl

Mandatory Refusal – when communications are lost, no one is trusted. A breach is assumed.

Gain Band Width Product = Gain x Bandwidth

CARVER is an acronym that stands for Criticality, Accessibility, Recuperability, Vulnerability, Effect and Recognizability.

Wind Speed Beaufort Category How to Judge the Wind
1-3 mph Light Air Smoke drifts. Wind cannot be felt.
4-7 mph Light Breeze Wind felt on face. Leaves rustle. Weather vanes move.
8-12 mph Gentle Breeze Leaves and twigs in motion. Light flags are extended.
13-18 mph Moderate Breeze Wind raises dust and loose papers. Small branches move. Flags flap.
19-24 mph Fresh Breeze Small trees in leaf sway slightly. Wavelets form on ponds and lakes.
25-31 mph Strong Breeze Large branches move. Telephone lines sing.

Visible Light – 400 to 700 nm

adam boy charles david edward frank george henry ida john kevin lincoln mary nora ocean paul queen robert sam tom union victor william xray young zebra
bull spread buy near, sell far
bear spread sell near, buy farcash – futures = basis

spreads are differences between futures contract months
cashpostive carry
cash>futures negative carry (inverted)
Basis: time space quality

Aromatic: planar, cyclic, Huckels Rule – 4n+2 electrons

Fibrous – sclera, cornea

Sensory – retina

Vascular – choroid, iris, pupil, ciliary body

Kingdoms – monera, protista, fungi, plant, animal

HSbF6 pKa = 25

Electrophiles are positive, nucleophiles are negative

EDTA is a tetraprotic acid.

C-C=O-C Ketone

Ketones containing alkene and alkyne units are often called unsaturated ketones.

Ph2CO Benzophenone

Sunflower 8 benzenes fused together

(H3C)(CO)(CO)(CH3) Diacetyl

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