Home > Uncategorized > University of Hawaii: Cancer and Chemo

University of Hawaii: Cancer and Chemo

Overview

I think we did this lecture already.  No matter.  It’s good to review frequently.  This lecture is on cancer and a host of cancer drugs.

http://www.youtube.com/watch?v=gQwIPFGXSKg

Details

Cancer occurs because of a loss of regulation.  They compress surrounding anaomy, synthesize abnormal hormones, reduced vascular ability, cause cachexia and malnutrition.  Damaged DNA is inherited in 10% of all cases. 

More often the environment is to blame.  UV, drugs, asbestos, ROH, smoking. Viruses can cause cancer; oncogenic viruses. 

T cells and lympocytes can attack tumors.  Most cancers form as a solid mass.  Leukemia and myeloma are liquid tumors. 

Carcinomas cover external/internal surfaces.  Most common.  Sarcomas are found in supporting tissues.  The primary site or oringinating site names the cancer. 

TNM Staging. 

T=tumor.  Primary tumor and its size.  T1-T4 describes size and level of invasion. 

N = lymph node.  N0-N3. 

M=metastasis.  M0 – M1. 

Combine TNM to get staging. 

Cancer Drug Subclasses

The cell cycle is M, G0, G1, S, G2.  M phase is mitosis phase. 

Alkalating Agents

Mustard agents are quite effective.  N7 position fo guanine. 

Antimetabolites

Plant Alkaloids

Antibiotics

Hormones

Biologic Response Modifiers

Neoadjunct therapy is chemo before surgery. 

Review

A lactone is a cyclic ester

R-(O=S=O)-NH2 is a sulfonamide

The beta lactam ring is a (C=O)NHCH2CH2

Chloramine – NHCl2, NH2Cl, NCl3

Nitroso R-N=O

Nitrous Acid R-O-N=O 3.4

Cyanate H-N=C=O

shape shine shadow silhoutee

mEq = AW / (V x 1000)

horizontal/vertical/diagonal spread

30 households per man per hour, 100 men, 1000 houses, 3 hours

pH = pK + log base/acid

  • Stay relaxed
  • Weapon moves first
  • Accelerate the weapon
  • Move towards the target
  • Penetrate

Acetyl COCH3

Thionyl chloride SOCl2

Barchan Dune 35 degrees down, 15 up

R-N=N-R Azo

Ambush – linear, L, V

C=S Thioketone

H2N(C=O)NH2 Urea

cash-futures = basis

+ basis negative carry

– basis positive carry

4 carbons overwhelm hydrogen bonding

Atmosphere: troposphere, stratosphere, mesosphere, thermosphere, ionosphere, exosphere

CTLSC 7 12 554

Sextuple Bond: Mo2, W2

Intermolecular Bonding: electrostatic, h bonding, dipole dipole, van der Waals

Hydrogen Bonding: FON Cl

Mandatory Refusal – when communications are lost, no one is trusted. A breach is assumed.

Gain Band Width Product = Gain x Bandwidth

CARVER is an acronym that stands for Criticality, Accessibility, Recuperability, Vulnerability, Effect and Recognizability.

Wind Speed Beaufort Category How to Judge the Wind
1-3 mph Light Air Smoke drifts. Wind cannot be felt.
4-7 mph Light Breeze Wind felt on face. Leaves rustle. Weather vanes move.
8-12 mph Gentle Breeze Leaves and twigs in motion. Light flags are extended.
13-18 mph Moderate Breeze Wind raises dust and loose papers. Small branches move. Flags flap.
19-24 mph Fresh Breeze Small trees in leaf sway slightly. Wavelets form on ponds and lakes.
25-31 mph Strong Breeze Large branches move. Telephone lines sing.

Visible Light – 400 to 700 nm

adam boy charles david edward frank george henry ida john kevin lincoln mary nora ocean paul queen robert sam tom union victor william xray young zebra
bull spread buy near, sell far
bear spread sell near, buy farcash – futures = basis

spreads are differences between futures contract months
cashpostive carry
cash>futures negative carry (inverted)
Basis: time space quality

Aromatic: planar, cyclic, Huckels Rule – 4n+2 electrons

Fibrous – sclera, cornea

Sensory – retina

Vascular – choroid, iris, pupil, ciliary body

Kingdoms – monera, protista, fungi, plant, animal

HSbF6 pKa = 25

Electrophiles are positive, nucleophiles are negative

EDTA is a tetraprotic acid.

C-C=O-C Ketone

Ketones containing alkene and alkyne units are often called unsaturated ketones.

Ph2CO Benzophenone

Sunflower 8 benzenes fused together

(H3C)(CO)(CO)(CH3) Diacetyl

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